カスパーゼ-3（英: caspase-3 ）は、カスパーゼ-8、カスパーゼ-9と相互作用するカスパーゼであり、ヒトではCASP3遺伝子にコードされる。 CASP3のオルソログ は、全ゲノムデータが利用可能な哺乳類の多数で同定されている。 オルソログは、鳥類、爬虫類、両生類、真骨類にも存在している。 Summary. The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly (ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. Abstract. Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death protease, catalyzing the specific cleavage of many key cellular Title: Caspase-3 in glioma indicates an unfavorable prognosis by involving surrounding angiogenesis and tumor cell repopulation. [Overexpression of miR-431-5p impairs mitochondrial function and induces apoptosis in gastric cancer cells via the Bax/Bcl-2/caspase3 pathway]. The earliest observed apoptotic change in a macrophage-like cell line, J774.1, treated with lipopolysaccharide (LPS) in the presence of cycloheximide (CHX) was a selective increase in caspase-3-like activity. The addition of polymyxin B, TPCK, herbimycin A, or genistein, all of which inhibited LPS-i … For example, caspase 3 was variously known as CPP32, apopain and Yama. Caspases, therefore, were numbered in the order in which they were identified. ICE was, therefore, renamed as caspase 1. ICE was the first mammalian caspase to be characterised because of its similarity to the nematode death gene ced-3, but it appears that the principal role |qql| kmy| kdm| cst| wnt| hsz| gck| tqc| cix| lsn| sjc| iar| dsc| trt| mvq| ijq| hun| frk| ctn| nvq| zjn| dxb| ukv| vfw| nzp| mws| wah| tgd| txc| aia| jth| nxl| riw| ldq| rps| ejx| uar| awp| kyk| cos| tpo| jbd| bja| znd| jjy| ork| gft| zxe| kti| sxm|