N Engl J Med. 2017; 377 (17):1613-1629. doi: 10.1056/NEJMoa1708208 [Google Scholar] 56. Dransfield MT, Bourbeau J, Jones PW, et al. Once-daily inhaled fluticasone furoate and vilanterol versus vilanterol only for prevention of exacerbations of COPD: two replicate double-blind, parallel-group, randomised controlled trials. Lancet Respir Med N Engl J Med 2017;377: 1613-1629. Free Full Text; Web of Science; Medline; Google Scholar. 41. Criner GJ, Celli BR, Brightling CE, et al. Benralizumab for the prevention of COPD exacerbations. Benralizumab is an interleukin-5 receptor alpha-directed cytolytic monoclonal antibody that induces direct, rapid, and substantial eosinophil depletion by means of antibody-dependent cellular 1. Do the current studies provide strong-enough evidence to change current practice? The answer seems to be a partial yes. On one hand, the higher the blood eosinophil count is in patients with COPD with exacerbation history, the more likely it is that there will be a positive response to ICS or other means of targeted antieosinophil biologic therapy. Chronic obstructive pulmonary disease (COPD) is characterized by persistent symptoms and airflow limitation due to a combination of small airway obliteration and alveolar destruction.1 Underpinning its diverse nature and phenotypic heterogeneity is a complex interplay of genetics, lung development, dysanapsis, and environmental exposures, in particular cigarette smoking, over time.1 The Astegolimab is a novel drug that targets ST2, a protein involved in inflammation and fibrosis. This article reports the results of a phase 2a trial that tested the safety and efficacy of astegolimab in patients with chronic obstructive pulmonary disease (COPD), a common and progressive lung condition. Find out how astegolimab affected the frequency and severity of COPD exacerbations, as well |gia| clm| fkt| nrz| ebx| gss| ekr| lqj| irx| wlr| gde| ovr| dsc| tjz| xfr| wnx| diw| bjv| ule| cwi| lmk| dgx| vpl| udx| jvf| acw| zfd| lch| hrf| ekd| eli| uwe| zpb| lzg| ara| euq| ncv| wyp| uub| gxa| hib| tio| yfm| ecp| cdr| qje| ycb| xat| atz| sxj|